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ADME for the Medicinal Chemist
Join SMi as this Masterclass will provide an overview of the ADME process and covers concepts such as solubility, permeability, Pgp, CYP 450’s, Phase 1 & 2 metabolism, glomerular filtration and enteropathic cycling. Interactive workshops place heavy emphasis on the use of current medicinal chemistry literature to solve recurrent ADME issues. Using the ‘succeed through the literature approach’ participants will distil out working solutions to issues such as solubility, oral absorption, CNS penetration and duration of action. Drug ADME is presented through a biological overview of the digestive system as recently published (Wiley book). The first session covers absorption, permeability, PgP, CYP metabolism, first and second pass, biliary and renal excretion. It is followed by a round table discussion on routes of administration. A second session focuses on permeability, Pgp and CYP 450. The ensuing workshop examines 4 key publications to distil working solutions to key ADME issues: solubility, Pgp, hepatic and renal clearance. Why should you attend? Medicinal chemists with up to 5 years in industry. Academics who wish to acquaint themselves with key issues in the drug discovery process. The session is suitable to graduates, PhD and Post Doctoral fellows and assumes no prior knowledge. This Masterclass will be hosted by: Corinne Kay, Company Director, Med-Simple For full conference programme please visit: www.smi-online.co.uk/2014adme-mc2.asp For more information please contact: Daniel Lee on +44 (0) 207 827 6078 or email at email@example.com